Technology Process of 1,3-bis(4-nitrophenyl) 2-(2-fluorophenyl)propanedioate
There total 4 articles about 1,3-bis(4-nitrophenyl) 2-(2-fluorophenyl)propanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2-fluorophenyl)propanedioic acid;
With
thionyl chloride;
In
N,N-dimethyl-formamide; toluene;
at 25 - 50 ℃;
for 3.83333h;
Inert atmosphere;
4-nitro-phenol;
In
N,N-dimethyl-formamide; toluene;
at 49 - 55 ℃;
for 1.75h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium methylate / toluene / 5.25 h / 70 - 75 °C / Inert atmosphere
1.2: 10 - 15 °C
2.1: thionyl chloride / 19.75 h / 0 - 45 °C / Inert atmosphere
3.1: tetramethlyammonium chloride; sodium hydroxide; water / 10 - 32 °C
3.2: 1 h / 5 - 10 °C / pH 2
4.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 3.83 h / 25 - 50 °C / Inert atmosphere
4.2: 1.75 h / 49 - 55 °C
With
thionyl chloride; water; sodium methylate; tetramethlyammonium chloride; sodium hydroxide;
In
N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / 19.75 h / 0 - 45 °C / Inert atmosphere
2.1: tetramethlyammonium chloride; sodium hydroxide; water / 10 - 32 °C
2.2: 1 h / 5 - 10 °C / pH 2
3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 3.83 h / 25 - 50 °C / Inert atmosphere
3.2: 1.75 h / 49 - 55 °C
With
thionyl chloride; water; tetramethlyammonium chloride; sodium hydroxide;
In
N,N-dimethyl-formamide; toluene;
