(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one
CAS No.:1027413-76-8
Molecular Formula:C₁₅H₂₀FN₃O₂S
Molecular Weight:325.407
Hs Code.:

Synonyms:(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

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Chemical Property of (S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

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Technology Process of (S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

There total 11 articles about (S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (R)-5-(azidomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

: 1027413-76-8
(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 - 25 ℃;

Reference yield:

: C₁₆H₂₁FN₂O₅S₂

: 1027413-76-8
(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

Guidance literature:: With ammonia; In tetrahydrofuran; methanol; at 100 ℃; for 72h; Heating / reflux;

Reference yield:

: 6309-59-7
tetrahydro-4H-thiopyran-4-one oxime

: 1027413-76-8
(S)-5-(aminomethyl)-3-(3-fluoro-4-(1,4-thiazepan-4-yl)phenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: polyphosphoric acid / 0.25 h / 115 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 - 80 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / -20 - 0 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C

7.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8.1: potassium carbonate; sodium azide / N,N-dimethyl-formamide / 1 h / 25 - 80 °C / Inert atmosphere

9.1: hydrogen; palladium on activated charcoal / methanol / 20 - 25 °C

With lithium aluminium tetrahydride; n-butyllithium; sodium azide; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;