methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

Base Information

• Chemical Name: methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate
• CAS No.: 118133-83-8
• Molecular Formula: C₂₇H₂₄N₂O₅
• Molecular Weight: 456.498

Synonyms:methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

Chemical Property of methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

Chemical Property:

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Technology Process of methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

There total 3 articles about methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-phenyl-maleimide (941-69-5) + methyl (E)-2-((2-methoxybenzylidene)amino)-2-phenylacetate (83572-73-0,88967-38-8,118133-81-6) → methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate (118133-83-8)

Guidance literature:

acetic acid; In acetic anhydride; acetic acid; for 0.75h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87794-2

Reference yield:

DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7) → methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate (118133-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / MgSO₄/triethylamine / CH₂Cl₂ / 18 h

2: 88 percent / acetic acid / acetic anhydride; acetic acid / 0.75 h / Ambient temperature

With magnesium sulfate; triethylamine; acetic acid; In dichloromethane; acetic anhydride; acetic acid;

DOI:10.1016/S0040-4020(01)87794-2

Reference yield:

ortho-anisaldehyde (135-02-4) → methyl c-4 (o-methoxyphenyl)-2,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate (118133-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / MgSO₄/triethylamine / CH₂Cl₂ / 18 h

2: 88 percent / acetic acid / acetic anhydride; acetic acid / 0.75 h / Ambient temperature

With magnesium sulfate; triethylamine; acetic acid; In dichloromethane; acetic anhydride; acetic acid;

DOI:10.1016/S0040-4020(01)87794-2

upstream raw materials:

N-phenyl-maleimide

methyl (E)-2-((2-methoxybenzylidene)amino)-2-phenylacetate

DL-2-phenylglycine methyl ester hydrochloride

ortho-anisaldehyde

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