Technology Process of (1S,4R,5R,6R)-4-(2,4-difluorobenzyloxy)-6-hydroxy-2,8-dioxa-bicyclo[3.3.0]octane
There total 4 articles about (1S,4R,5R,6R)-4-(2,4-difluorobenzyloxy)-6-hydroxy-2,8-dioxa-bicyclo[3.3.0]octane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; water;
at 20 ℃;
for 5h;
DOI:10.1021/ml2000356
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / Inert atmosphere
1.2: 20 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere
3.2: 3 h / 0 - 20 °C / Inert atmosphere
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 5 h / 20 °C
With
tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1021/ml2000356
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere
2.2: 3 h / 0 - 20 °C / Inert atmosphere
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 5 h / 20 °C
With
tetrabutyl ammonium fluoride; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1021/ml2000356