phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Base Information

Chemical Name:phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate
CAS No.:144876-77-7
Molecular Formula:C₃₅H₃₉N₅O₆
Molecular Weight:625.725
Hs Code.:

phenylmethyl<R-(R*,R*)>-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Synonyms:phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

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Chemical Property of phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

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Technology Process of phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

There total 10 articles about phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 144876-74-4
phenylmethyl -4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1-<1-<<2-(triemthylsilyl)ethoxy>carbonyl>cyclohexyl>-1,3,6,9-tetraazadecan-10-oate

: 144876-77-7
phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 17h;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 144876-77-7
phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent

2: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

3: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

4: 96 percent / NEt₃ / tetrahydrofuran / 25 °C

5: 81 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

6: 95 percent / TFA / CH₂Cl₂ / 17 h / 25 °C

With dmap; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 17191-43-4
1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

: 144876-77-7
phenylmethyl-1-(1-carboxycyclohexyl)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

2: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

3: 96 percent / NEt₃ / tetrahydrofuran / 25 °C

4: 81 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

5: 95 percent / TFA / CH₂Cl₂ / 17 h / 25 °C

With dmap; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)86596-0