1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

Base Information

Chemical Name:1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride
CAS No.:1609575-44-1
Molecular Formula:C₂₅H₂₄ClF₆N₃*ClH
Molecular Weight:552.39
Hs Code.:

Synonyms:1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

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Chemical Property of 1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

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Technology Process of 1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

There total 5 articles about 1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1609575-69-0
2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate

: 1609575-44-1
1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

Guidance literature:: 2-(4-chlorophenyl)-2-oxoethyl 4,4,4-trifluoro-3-((3-(3-(trifluoromethyl)-phenyl)piperidin-1-yl)methyl)butanoate; With ammonium acetate; acetic acid; at 120 ℃; for 0.5h; Microwave irradiation; Sealed tube;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; hexane;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-44-1
1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: acetic acid; ammonium acetate / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With ethanol; ammonium acetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 4,4,4-trifluoro-3-formyl-butyric acid ethyl ester

: 1609575-44-1
1-{2-[5-(4-chlorophenyl)-1H-imidazol-2-ylmethyl]-3,3,3-trifluoro-propyl}-3-(3-trifluoromethyl-phenyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

2: sodium hydroxide; ethanol / 0.5 h / 90 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: acetic acid; ammonium acetate / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With ethanol; ammonium acetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;