(S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide

Base Information

• Chemical Name: (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide
• CAS No.: 1416797-67-5
• Molecular Formula: C₂₀H₁₄F₄N₄O₂
• Molecular Weight: 418.35

Synonyms:(S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide

Chemical Property of (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide

There total 2 articles about (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride (1416946-42-3) + 5-cyano-pyridine-2-carboxylic acid (53234-55-2) → (S)-N2-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide (1416797-67-5)

Guidance literature:

(S)-(3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride; 5-cyano-pyridine-2-carboxylic acid; With HATU; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

With sulfuric acid; water; In dichloromethane; for 5h; Cooling with ice;

Reference yield:

→ (S)-N2-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)pyridine-2,5-dicarboxamide (1416797-67-5)

Guidance literature:

upstream raw materials:

(S)-(3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride

5-cyano-pyridine-2-carboxylic acid

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