methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Base Information

Chemical Name:methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate
CAS No.:955360-39-1
Molecular Formula:C₂₀H₂₀ClNO₅
Molecular Weight:389.835
Hs Code.:

Synonyms:methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Suppliers and Price of methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

There total 4 articles about methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 24202-74-2
4-(methoxycarbonyl)nicotinic acid

: 33155-59-8
tert-butyl 2-(4-chlorophenyl)acetate

: 955360-39-1
methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Guidance literature:: 4-(methoxycarbonyl)nicotinic acid; In N,N-dimethyl-formamide; at 50 ℃; for 1.5h;

tert-butyl 2-(4-chlorophenyl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 2.41667h;

Reference yield: 75.0%

: 33155-59-8
tert-butyl 2-(4-chlorophenyl)acetate

: 955360-39-1
methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Guidance literature:: 4-(methoxycarbonyl)nicotinic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 50 ℃; for 1.5h;

tert-butyl 2-(4-chlorophenyl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 2.41667h;

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 955360-39-1
methyl 3-{2-(4-chlorophenyl)-3-[(1,1-dimethylethyl)oxy]-3-oxopropanoyl}-4-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / tetrahydrofuran / 18 h / -70 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h / 50 °C / Inert atmosphere

2.2: 2 h / -5 - 20 °C / Inert atmosphere

With sodium methylate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.08.032