4-(METHOXYCARBONYL)NICOTINIC ACID

Base Information

• Chemical Name: 4-(METHOXYCARBONYL)NICOTINIC ACID
• CAS No.: 24202-74-2
• Molecular Formula: C8H7NO4
• Molecular Weight: 181.148
• Hs Code.: 29339900
• Mol file: 24202-74-2.mol

Synonyms:4-(Methoxycarbonyl)nicotinicacid;4-(Methoxycarbonyl)pyridine-3-carboxylic acid;4-Carbomethoxynicotinicacid;4-[(Methyloxy)carbonyl]-3-pyridinecarboxylic acid;NSC 302958;

Chemical Property of 4-(METHOXYCARBONYL)NICOTINIC ACID

Chemical Property:

• Vapor Pressure: 1.15E-05mmHg at 25°C
• Melting Point: 183-185 °C
• Refractive Index: 1.56
• Boiling Point: 355.4 °C at 760 mmHg
• PKA: 2?+-.0.18(Predicted)
• Flash Point: 168.8 °C
• PSA: 76.49000
• Density: 1.361 g/cm³
• LogP: 0.56640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-(Methoxycarbonyl)nicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(METHOXYCARBONYL)NICOTINIC ACID

There total 7 articles about 4-(METHOXYCARBONYL)NICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

cinchomeronic anhydride (4664-08-8) + ethanol (64-17-5) → 4-(methoxycarbonyl)nicotinic acid (24202-74-2)

Guidance literature:

Reference yield: 82.0%

methanol (67-56-1) + cinchomeronic anhydride (4664-08-8) → pyridine-3,4-dicarboxylic acid 3-methyl ester (24202-79-7) + 4-(methoxycarbonyl)nicotinic acid (24202-74-2)

Guidance literature:

In dichloromethane; for 18h; Ambient temperature;

DOI:10.1039/P19910003165

Reference yield: 73.0%

cinchomeronic anhydride (4664-08-8) + sodium methylate (124-41-4) → 4-(methoxycarbonyl)nicotinic acid (24202-74-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; water; 1.) from -70 deg C to RT, overnight, 2.) 0 deg C;

DOI:10.1021/jo00350a001

upstream raw materials:

methanol

cinchomeronic anhydride

pyridine-3,4-dicarboxylic acid 3-methyl ester

ethanol

Downstream raw materials:

dimethyl 3,4-pyridinedicarboxylate

pyridin-3-carboxylic acid-4-carboxamide

3,4-pyridinecarboxylic acid

1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone