3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Base Information

Chemical Name:3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile
CAS No.:261157-03-3
Molecular Formula:C₂₀H₃₂N₂O₃SSi
Molecular Weight:408.637
Hs Code.:

Synonyms:3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Suppliers and Price of 3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

There total 6 articles about 3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 261156-79-0
(E)-3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acrylonitrile

: 261157-03-3
3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1002/(SICI)1521-3773(20000103)39

Reference yield:

: 16257-57-1
methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate

: 261157-03-3
3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / imidazole / CH₂Cl₂

2: 98 percent / DIBAL-H / toluene / -78 - 20 °C

3: DMSO; (COCl)2; NEt₃ / CH₂Cl₂ / -78 °C

4: CH₂Cl₂ / -78 - 20 °C

5: 98 percent / H₂ / 10 percent Pd/C / ethyl acetate

With 1H-imidazole; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene; 1: Etherification / 2: Reduction / 3: Oxidation / 4: Condensation / 5: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3773(20000103)39

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 261157-03-3
3-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / imidazole / CH₂Cl₂

2: 98 percent / DIBAL-H / toluene / -78 - 20 °C

3: DMSO; (COCl)2; NEt₃ / CH₂Cl₂ / -78 °C

4: CH₂Cl₂ / -78 - 20 °C

5: 98 percent / H₂ / 10 percent Pd/C / ethyl acetate

With 1H-imidazole; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene; 1: Etherification / 2: Reduction / 3: Oxidation / 4: Condensation / 5: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3773(20000103)39