3,3-DIMETHYL-6-NITROINDOLINE

Base Information

• Chemical Name: 3,3-DIMETHYL-6-NITROINDOLINE
• CAS No.: 179898-72-7
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Hs Code.: 2933990090
• Mol file: 179898-72-7.mol

Synonyms:3,3-Dimethyl-6-nitro-2,3-dihydro-1H-indole;3,3-Dimethyl-6-nitroindoline;

Chemical Property of 3,3-DIMETHYL-6-NITROINDOLINE

Chemical Property:

• Boiling Point: 301.731 °C at 760 mmHg
• Flash Point: 136.282 °C
• PSA: 57.85000
• Density: 1.166 g/cm³
• LogP: 2.95910
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3-Dimethyl-6-nitroindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-DIMETHYL-6-NITROINDOLINE

There total 8 articles about 3,3-DIMETHYL-6-NITROINDOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,3-dimethyl-indoline; hydrochloride → 3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole (179898-72-7)

Guidance literature:

3,3-dimethyl-indoline; hydrochloride; With sulfuric acid; nitric acid; In water; at -15 - 10 ℃; Inert atmosphere;

With ammonium hydroxide; In water; at 0 - 5 ℃; pH=8 - 9;

Reference yield:

1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone (453562-68-0) → 3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole (179898-72-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 70 ℃;

Reference yield:

2-bromo-N-(2-methyl-2-propenyl)-5-nitroaniline (179898-71-6) + Bu4 NBr → 3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole (179898-72-7)

Guidance literature:

With sodium formate; triethylamine; palladium diacetate; In water; N,N-dimethyl-formamide;

upstream raw materials:

3,3-dimethylindoline

1,3-Dihydro-3,3-dimethyl-6-nitro-2H-indol-2-one

2-bromoaniline

(2-Bromo-phenyl)-(2-methyl-allyl)-amine

Downstream raw materials:

1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone

1,3,3-trimethylindoline-6-ylamine

6-amino-3,3-dimethylindoline

Refernces

• 1、 -. "COMPOUNDS AND METHODS OF USE". Page/Page column 119. . Retrieved 2010/11/27.
• 2、 -. "SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE". Page/Page column 161. . Retrieved 2008/06/13.