4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

Base Information

Chemical Name:4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine
CAS No.:1427555-48-3
Molecular Formula:C₂₃H₂₅ClN₄O₂
Molecular Weight:424.93
Hs Code.:

Synonyms:4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

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Chemical Property of 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

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Technology Process of 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

There total 6 articles about 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 1334711-86-2
4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine

: 1427555-48-3
4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 271-29-4
6-azaindole

: 1427555-48-3
4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol / 18 h / 70 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 90 °C / 67506.8 Torr

3: N,N`-dimethylethylenediamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h

5: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With dmap; potassium phosphate; copper(l) iodide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; N,N`-dimethylethylenediamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1334711-85-1
tert-butyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

: 1427555-48-3
4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With dmap; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;