(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

Base Information

Chemical Name:(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone
CAS No.:1403941-67-2
Molecular Formula:C₂₂H₂₃F₃N₄O₃
Molecular Weight:448.445
Hs Code.:

Synonyms:(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

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Chemical Property of (2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

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Technology Process of (2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

There total 4 articles about (2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403942-36-8
C₉H₉N₃O₂

: 287952-22-1
4-((4-(trifluoromethoxy)benzyl)oxy)piperidine hydrochloride

: 1403941-67-2
(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 87943-99-5
ethyl 2-bromo-3-oxopentanoate

: 1403941-67-2
(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / Reflux

2: lithium hydroxide; water / ethanol / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 80 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1403941-67-2
(2-ethylimidazo[1,2-a]pyrazin-3-yl)(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate; N-Bromosuccinimide / diethyl ether / 6 h / 20 °C

2: ethanol / Reflux

3: lithium hydroxide; water / ethanol / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 80 °C

With N-Bromosuccinimide; ammonium acetate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In diethyl ether; ethanol; N,N-dimethyl-formamide;