287952-22-1Relevant academic research and scientific papers
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6
Shen, Yudao,Szewczyk, Magdalena M.,Eram, Mohammad S.,Smil, David,Kaniskan, H. ümit,Ferreira De Freitas, Renato,Senisterra, Guillermo,Li, Fengling,Schapira, Matthieu,Brown, Peter J.,Arrowsmith, Cheryl H.,Barsyte-Lovejoy, Dalia,Liu, Jing,Vedadi, Masoud,Jin, Jian
, p. 9124 - 9139 (2016/10/22)
Well-characterized selective inhibitors of protein arginine methyltransferases (PRMTs) are invaluable chemical tools for testing biological and therapeutic hypotheses. Based on 4, a fragment-like inhibitor of type I PRMTs, we conducted structure-activity
