(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

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Chemical Name:(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone
CAS No.:277330-99-1
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

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Chemical Property of (+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

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Technology Process of (+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

There total 3 articles about (+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100-39-0
benzyl bromide

: 277330-97-9
(+)-(3S,4R)-trans-1-(p-methoxyphenyl)-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2-azetidinone

: 277330-99-1
(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

Guidance literature:: With sodium hydroxide; tetrabutylammonium iodide benzyl bromide; In dichloromethane; water; at 20 ℃; for 4h;
DOI:10.1021/jo991984h

Reference yield:

: 103174-02-3
(3R,4S)-cis-1-(p-anisyl)-3-acetoxy-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>azetidin-2-one

: 277330-99-1
(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

2: 91 percent / NaOMe / methanol / 0.5 h / 0 °C

3: 80 percent / NaOH; tetrabutylammonium iodide benzyl bromide / CH₂Cl₂; H₂O / 4 h / 20 °C

With sodium hydroxide; tetrabutylammonium iodide benzyl bromide; sodium methylate; In methanol; dichloromethane; water; 1: Isomerization / 2: Hydrolysis / 3: Alkylation;
DOI:10.1021/jo991984h

Reference yield:

: 277330-95-7
(3S,4S)-trans-1-(p-anisyl)-3-acetoxy-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>azetidin-2-one

: 277330-99-1
(+)-(3S,4S)-trans-1-(p-methoxyphenyl)-3-benzyloxy-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NaOMe / methanol / 0.5 h / 0 °C

2: 80 percent / NaOH; tetrabutylammonium iodide benzyl bromide / CH₂Cl₂; H₂O / 4 h / 20 °C

With sodium hydroxide; tetrabutylammonium iodide benzyl bromide; sodium methylate; In methanol; dichloromethane; water; 1: Hydrolysis / 2: Alkylation;
DOI:10.1021/jo991984h