16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

Base Information

Chemical Name:16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one
CAS No.:870625-86-8
Molecular Formula:C₄₁H₆₀O₃Si₂
Molecular Weight:657.097
Hs Code.:

Synonyms:16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

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Technology Process of 16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

There total 2 articles about 16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 870625-83-5
16α-hydroxy-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 870625-86-8
16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃;
DOI:10.1021/jo051536b

Reference yield:

: 16-bromo-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

: 870625-86-8
16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / aq. NaOH / CH₂Cl₂; dimethylformamide / 20 °C

2: 86 percent / imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo051536b

Reference yield: 43.0%

: 870625-86-8
16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one

: 105-37-3,20741-13-3
Ethyl propionate

: 870625-91-5
2-[16-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-propionic acid ethyl ester

Guidance literature:: Ethyl propionate; With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 0.5h;

16α-(tert-butyldimethylsiloxy)-3β-(tert-butyldiphenylsiloxy)-5-androsten-17-one; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1021/jo051536b