1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Base Information

Chemical Name:1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]
CAS No.:764680-82-2
Molecular Formula:C₄₄H₆₆N₆O₁₀S₄
Molecular Weight:967.306
Hs Code.:

Synonyms:1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

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Chemical Property of 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

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Technology Process of 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

There total 6 articles about 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 110-85-0
piperazine

: 343308-55-4
(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 764680-82-2
1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Guidance literature:: With potassium carbonate; In acetone; for 48h; Heating;
DOI:10.1016/j.bmc.2005.08.020

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 764680-82-2
1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / potassium carbonate / acetone / 48 h / Heating

2: 90 percent / stannic chloride; fuming nitric acid / CH₂Cl₂ / 0.08 h / -25 °C

3: 89 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O; methanol / 12 h / 20 °C

4: thionyl chloride; DMF / benzene / 6 h

5: 464 mg / triethylamine / tetrahydrofuran; H₂O

6: 85 percent / potassium carbonate / acetone / 48 h / Heating

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; benzene;
DOI:10.1016/j.bmc.2005.08.020

Reference yield:

: 343308-52-1
4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoic acid

: 764680-82-2
1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; DMF / benzene / 6 h

2: 464 mg / triethylamine / tetrahydrofuran; H₂O

3: 85 percent / potassium carbonate / acetone / 48 h / Heating

With thionyl chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; water; acetone; benzene;
DOI:10.1016/j.bmc.2005.08.020