1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Base Information

• Chemical Name: 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]
• CAS No.: 871813-96-6
• Molecular Formula: C₄₄H₇₀N₆O₆S₄
• Molecular Weight: 907.34
• Mol file: 871813-96-6.mol

Synonyms:1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Chemical Property of 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

There total 7 articles about 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] (764680-82-2) → 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] (871813-96-6)

Guidance literature:

With tin(ll) chloride; In methanol; for 1.5h; Heating;

DOI:10.1016/j.bmc.2005.08.020

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] (871813-96-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 86 percent / potassium carbonate / acetone / 48 h / Heating

2: 90 percent / stannic chloride; fuming nitric acid / CH₂Cl₂ / 0.08 h / -25 °C

3: 89 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O; methanol / 12 h / 20 °C

4: thionyl chloride; DMF / benzene / 6 h

5: 464 mg / triethylamine / tetrahydrofuran; H₂O

6: 85 percent / potassium carbonate / acetone / 48 h / Heating

7: SnCl₂*2H₂O / methanol / 1.5 h / Heating

With lithium hydroxide; thionyl chloride; nitric acid; tin(IV) chloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; water; acetone; benzene;

DOI:10.1016/j.bmc.2005.08.020

Reference yield:

(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (343308-55-4) → 1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy 2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] (871813-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / potassium carbonate / acetone / 48 h / Heating

2: SnCl₂*2H₂O / methanol / 1.5 h / Heating

With potassium carbonate; tin(ll) chloride; In methanol; acetone;

DOI:10.1016/j.bmc.2005.08.020

upstream raw materials:

1,1'-{[(bispropane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-nitrobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal]

4-hydroxy-3-methoxybenzoic acid methyl ester

(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

methyl 4-(3-bromopropoxy)-3-methoxybenzoate