N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

Base Information

Chemical Name:N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester
CAS No.:162610-63-1
Molecular Formula:C₂₃H₃₁N₃O₅
Molecular Weight:429.516
Hs Code.:

Synonyms:N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

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Chemical Property of N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

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Technology Process of N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

There total 6 articles about N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 162610-61-9
1-(Benzyloxy)-3-(carboxyethyl)-5,6-dimethyl-2(1H)-pyrazinone

: 162610-63-1
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00111a015

Reference yield:

: 622-33-3
N-benzyloxyamine

: 162610-63-1
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N, isobutyl chloroformate / 1.) THF, -17 deg C, 15 min, 2.) THF, r.t., overnight

2: 4 N HCl / dioxane / 0 °C

3: 43 percent / aq. NaOH / methanol / 2 h / Ambient temperature

4: 89 percent / 1 N NaOH / methanol / 6.5 h / Ambient temperature

5: 60 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N-methylmorpholine, HOBt / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a015

Reference yield:

: 45214-91-3
(2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid

: 162610-63-1
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₃N, isobutyl chloroformate / 1.) THF, -17 deg C, 15 min, 2.) THF, r.t., overnight

2: 4 N HCl / dioxane / 0 °C

3: 43 percent / aq. NaOH / methanol / 2 h / Ambient temperature

4: 89 percent / 1 N NaOH / methanol / 6.5 h / Ambient temperature

5: 60 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N-methylmorpholine, HOBt / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a015