(4S,5S,R/S)-(+)-phenylacetonitrile

Base Information

Chemical Name:(4S,5S,R/S)-(+)-phenylacetonitrile
CAS No.:202288-49-1
Molecular Formula:C₂₁H₂₄N₂O₂
Molecular Weight:336.434
Hs Code.:

(4S,5S,R/S)-(+)-<N-(2,2-dimethyl-4-phenyl-1,2-dioxan-5-yl)-N-methylamino>phenylacetonitrile

Synonyms:(4S,5S,R/S)-(+)-phenylacetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S,R/S)-(+)-phenylacetonitrile

Chemical Property:

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Technology Process of (4S,5S,R/S)-(+)-phenylacetonitrile

There total 1 articles about (4S,5S,R/S)-(+)-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124686-47-1
(4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan

: 151-50-8
potassium cyanide

: 100-52-7
benzaldehyde

: 202288-49-1
(4S,5S,R/S)-(+)-phenylacetonitrile

Guidance literature:: With hydrogenchloride; In methanol; water; pH 5-7, 0 deg C, then room t.;
DOI:10.1055/s-1995-3968

Reference yield:

: 202288-49-1
(4S,5S,R/S)-(+)-phenylacetonitrile

: (R)-4-Benzoyl-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -90 deg C, 1 h

2: 45 percent / 1N aq. AgNO₃ / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

With n-butyllithium; silver nitrate; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4020(96)00542-X

Reference yield:

: 202288-49-1
(4S,5S,R/S)-(+)-phenylacetonitrile

: (3S,4R)-4-Benzoyl-3-(2-methyl-allyl)-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi

2: 1N aq. AgNO₃ / tetrahydrofuran; diethyl ether / 6 h / Ambient temperature

With n-butyllithium; silver nitrate; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4020(96)00542-X