(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

Base Information

Chemical Name:(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one
CAS No.:1192123-14-0
Molecular Formula:C₁₇H₁₈O₆
Molecular Weight:318.326
Hs Code.:

Synonyms:(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

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Chemical Property of (S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

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Technology Process of (S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

There total 5 articles about (S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

: 1357023-58-5
C₂₉H₄₆O₆Si₂

: 1192123-14-0
(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

Guidance literature:: C₂₉H₄₆O₆Si₂; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1016/j.tetlet.2011.12.016

Reference yield:

: C₂₉H₄₈O₆Si₂

: 1192123-14-0
(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: methanol; potassium carbonate / 3 h / 20 °C / Inert atmosphere

3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With methanol; dmap; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; potassium carbonate; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.12.016

Reference yield:

: 1357023-51-8
C₂₉H₄₈O₆Si₂

: 1192123-14-0
(S)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.12.016