threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

Base Information

Chemical Name:threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol
CAS No.:1189197-77-0
Molecular Formula:C₁₇H₂₀O₆
Molecular Weight:320.342
Hs Code.:

Synonyms:threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

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Chemical Property of threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

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Technology Process of threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

There total 13 articles about threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1357023-59-6
C₂₀H₂₄O₆

: 1189197-77-0
threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.12.016

Reference yield:

: (1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

: 1189197-77-0
threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 3h; Inert atmosphere;
DOI:10.1002/chem.201601592

Reference yield:

: (R)-4-benzyl-3-(2-(2-methoxyphenoxy)acetyl)oxazolidin-2-one

: 1189197-77-0
threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

1.2: 4 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; hydrogen

3.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 °C

With sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/acs.orglett.7b00587