(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Base Information

Chemical Name:(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one
CAS No.:530440-10-9
Molecular Formula:C₂₂H₂₁F₆NO₂
Molecular Weight:445.405
Hs Code.:

Synonyms:(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Suppliers and Price of (S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

There total 7 articles about (S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 530440-15-4
(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-5,6-dihydro-1H-pyridin-2-one

: 530440-10-9
(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/j.tetasy.2006.09.022

Reference yield:

: 530441-99-7
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

: 530440-10-9
(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / Ti(iPrO)4

2: 63 percent / CH₂Cl₂ / -78 °C

3: HCl / diethyl ether

4: DIEA / CH₂Cl₂ / 0 °C

5: 60 percent / second generation Grubbs' catalyst

6: 87 percent / H₂ / Pd/C

With titanium(IV) isopropylate; hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In diethyl ether; dichloromethane;
DOI:10.1016/j.tetasy.2006.09.022

Reference yield:

: (S)-1-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-phenyl-but-3-enylamine

: 530440-10-9
(S)-6-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-6-phenyl-piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: DIEA / CH₂Cl₂ / 0 °C

2: 60 percent / second generation Grubbs' catalyst

3: 87 percent / H₂ / Pd/C

With hydrogen; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.tetasy.2006.09.022