rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane

Base Information

• Chemical Name: rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane
• CAS No.: 109669-15-0
• Molecular Formula: C₂₆H₃₁NO₂
• Molecular Weight: 389.538

Synonyms:rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane

Chemical Property of rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane

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Technology Process of rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane

There total 3 articles about rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dimethyl-[2-(4-{(1R,2S)-2-phenyl-1-[4-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenoxy)-phenyl]-butyl}-phenoxy)-ethyl]-amine (109640-24-6) → rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane (109669-15-0)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Yield given;

DOI:10.1021/jm00393a014

Reference yield:

(E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-15-5) → rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane (109669-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / HCOONH₄ / 10percent Pd/C / ethanol / 4.5 h / 80 °C

2: ethanol / 72 h / Heating

3: NaOMe / dimethylformamide / 2 h / 40 °C

With ammonium formate; sodium methylate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00393a014

Reference yield:

rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane (109640-22-4) → rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane (109669-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 72 h / Heating

2: NaOMe / dimethylformamide / 2 h / 40 °C

With sodium methylate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00393a014

upstream raw materials:

Dimethyl-[2-(4-{(1R,2S)-2-phenyl-1-[4-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenoxy)-phenyl]-butyl}-phenoxy)-ethyl]-amine

(E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

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