1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate
CAS No.:1426096-36-7
Molecular Formula:C₁₇H₂₂BrFN₂O₃
Molecular Weight:401.276
Hs Code.:

Synonyms:1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

There total 1 articles about 1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 204688-61-9
2‐[(3S)‐1‐[(tert‐butoxy)carbonyl]pyrrolidin‐3‐yl]acetic acid

: 367-24-8
4-bromo-2-fluoroaniline

: 1426096-36-7
1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

Guidance literature:: ((3S)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinyl)acetic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.166667h;

4-bromo-2-fluoroaniline; In tetrahydrofuran; at 20 ℃; for 120h;

Reference yield:

: 1426096-36-7
1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1426096-37-8
N-(4-bromo-2-fluorophenyl)-2-[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]acetamide

Guidance literature:: 1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 48h;

cyclopropanecarboxylic acid chloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 1426096-36-7
1,1-dimethylethyl (3S)-3-{2-[(4-bromo-2-fluorophenyl)amino]-2-oxoethyl}-1-pyrrolidinecarboxylate

: 1426095-55-7
2-[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]-N-[2-fluoro-4-(1H-indol-5-yl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 48 h / 0 - 20 °C

1.2: 0.5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

2.2: 1 h / 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;