(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1262106-62-6
Molecular Formula:C₂₄H₂₀ClF₃N₄O₂
Molecular Weight:488.897
Hs Code.:

Synonyms:(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Chemical Property of (S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

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Technology Process of (S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

There total 9 articles about (S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262106-61-5
8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

: 1262106-62-6
(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

: 1262106-63-7
(R)-(-)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: With CHIRALCEL AD; In hexane; Isopropyl acetate; Resolution of racemate;

Reference yield:

: 601513-31-9
2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid

: 1262106-62-6
(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

: 1262106-63-7
(R)-(-)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 13.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / 4 h / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

4.2: 2 h / Reflux

5.1: sodium azide / dimethyl sulfoxide / 13 h / 70 °C

5.2: 1.5 h / 60 °C

5.3: 2 h / Reflux

6.1: CHIRALCEL AD / hexane; Isopropyl acetate / Resolution of racemate

With sodium azide; oxalyl dichloride; sodium hydride; triethylamine; HATU; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; Isopropyl acetate; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1242314-20-0
5-chloro-2-[4-chloro-2-(trifluoromethyl)phenyl]pentanoic acid

: 1262106-62-6
(S)-(+)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

: 1262106-63-7
(R)-(-)8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 13 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: sodium azide / dimethyl sulfoxide / 13 h / 70 °C

2.2: 1.5 h / 60 °C

2.3: 2 h / Reflux

3.1: CHIRALCEL AD / hexane; Isopropyl acetate / Resolution of racemate

With sodium azide; triethylamine; HATU; In hexane; Isopropyl acetate; dimethyl sulfoxide; N,N-dimethyl-formamide;