4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID

Base Information

• Chemical Name: 4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
• CAS No.: 601513-31-9
• Molecular Formula: C9H6ClF3O2
• Molecular Weight: 238.594
• Hs Code.: 2916399090
• Mol file: 601513-31-9.mol

Synonyms:(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol;Terephthalaldehydic acid;4-Carboxybenzaladehyde;[4-carboxyphenyl]methanone;[4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl](phenyl)methanol;4-formyl-benzoic acid;(4-Chloro-2-trifluoromethylphenyl)-acetic acid;4-carboxy-benzaldehyde;p-formyl-benzoic acid;Benzoic acid,4-formyl;p-carboxybenzaldehyde;Terephthaldehydic acid;para-formylbenzoic acid;2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid;

Chemical Property of 4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID

Chemical Property:

• Melting Point: 88-90℃
• Boiling Point: 269.9±35.0 °C(Predicted)
• PKA: 3.96±0.10(Predicted)
• PSA: 37.30000
• Density: 1.469±0.06 g/cm3(Predicted)
• LogP: 2.98590

Purity/Quality:

98%Min ^*data from raw suppliers

4-Chloro-2-(trifluoromethyl)phenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID

There total 1 articles about 4-CHLORO-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-but-2-ene (513-35-9) + Bu3SnCH=CH2 + vacuum-N2 + aq H2O2 + 4-chloro-2-trifluoromethyliodobenzene (23399-77-1) → 2-(4-chloro-2-trifluoromethyl-phenyl)-ethanol (618885-83-9) + 2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid (601513-31-9)

Guidance literature:

With aq NaOH; (Ph₃P)4Pd; In ethanol; toluene;

Reference yield: 60.0%

2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid (601513-31-9) + 2-mercapto-4-methoxybenzaldehyde (294674-98-9) → C17H10ClF3O2S

Guidance literature:

With pyridine; acetic anhydride; at 135 ℃; for 72h;

Reference yield: 25.0%

2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid (601513-31-9) + 1.3-chlorobromopropane (109-70-6) → 5-chloro-2-[4-chloro-2-(trifluoromethyl)phenyl]pentanoic acid (1242314-20-0)

Guidance literature:

With n-butyllithium;

DOI:10.1016/j.bmcl.2015.07.101

upstream raw materials:

2-methyl-but-2-ene

4-chloro-2-trifluoromethyliodobenzene

Downstream raw materials:

8-[4-chloro-2-(trifluoromethyl)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine

tert-butyl 5-chloro-2-[4-chloro-2-(trifluoromethyl)phenyl]pentanoate

5-chloro-2-[4-chloro-2-(trifluoromethyl)phenyl]pentanoic acid

2-{4-chloro-1-[4-chloro-2-(trifluoromethyl)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole