Technology Process of 3'-N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinylcarbonyl)-amido-AVE8063
There total 4 articles about 3'-N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinylcarbonyl)-amido-AVE8063 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-carboxy proxyl; 3-amino-deoxycombretastatin A4;
With
dmap;
In
dichloromethane;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
for 24h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.12.046
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic anhydride; triethylamine / 3 h / 140 °C
2.1: copper; quinoline / 2 h / 140 °C
3.1: acetic acid; zinc / 24 h / 20 °C
4.1: dmap / dichloromethane / 0.08 h / 20 °C / Inert atmosphere
4.2: 24 h / Inert atmosphere
With
quinoline; dmap; acetic anhydride; copper; acetic acid; triethylamine; zinc;
In
dichloromethane;
DOI:10.1016/j.bmc.2012.12.046
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid; zinc / 24 h / 20 °C
2.1: dmap / dichloromethane / 0.08 h / 20 °C / Inert atmosphere
2.2: 24 h / Inert atmosphere
With
dmap; acetic acid; zinc;
In
dichloromethane;
DOI:10.1016/j.bmc.2012.12.046
