1-(4-iodophenyl)-2-methyl-1H-imidazole

Base Information

• Chemical Name: 1-(4-iodophenyl)-2-methyl-1H-imidazole
• CAS No.: 179420-75-8
• Molecular Formula: C10H9 I N2
• Molecular Weight: 284.1
• DSSTox Substance ID: DTXSID70461366
• Nikkaji Number: J2.201.724A
• Wikidata: Q82285670
• Mol file: 179420-75-8.mol

Synonyms:1-(4-iodophenyl)-2-methyl-1H-imidazole;179420-75-8;1-(4-Iodo-phenyl)-2-methyl-1H-imidazole;1-(4-iodophenyl)-2-methylimidazole;1H-Imidazole, 1-(4-iodophenyl)-2-methyl-;SCHEMBL4668323;DTXSID70461366;REVPKMONQSPHGF-UHFFFAOYSA-N;MFCD09261230;4-(2-Methylimidazol-1-yl)iodobenzene;AKOS016005123;4-(2-Methylimidazol-1-yl)phenyliodide;4-(2-methylimidazol-1-yl)phenyl iodide;CS-0139412;FT-0764952;1-(4-Iodophenyl)-2-methyl-1H-imidazole,97%;1-(4-Iodophenyl)-2-methyl-1H-imidazole, AldrichCPR

Chemical Property of 1-(4-iodophenyl)-2-methyl-1H-imidazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.78530
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 283.98105
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

98% ^*data from raw suppliers

1-(4-Iodo-phenyl)-2-methyl-1H-imidazole >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CN1C2=CC=C(C=C2)I

Technology Process of 1-(4-iodophenyl)-2-methyl-1H-imidazole

There total 3 articles about 1-(4-iodophenyl)-2-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-methylimidazole (693-98-1) + 4-fluoro-1-iodobenzene (352-34-1) → 4-(2-methylimidazol-1-yl)phenyl iodide (179420-75-8)

Guidance literature:

2-methylimidazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-fluoro-1-iodobenzene; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

DOI:10.1248/cpb.53.965

Reference yield:

ethyl acetate-toluene + 2-methylimidazole (693-98-1) + 4-fluoro-1-iodobenzene (352-34-1) → 4-(2-methylimidazol-1-yl)phenyl iodide (179420-75-8)

Guidance literature:

In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

→ 4-(2-methylimidazol-1-yl)phenyl iodide (179420-75-8)

Guidance literature:

upstream raw materials:

2-methylimidazole

4-fluoro-1-iodobenzene

Downstream raw materials:

4-cyano-4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]}phenyl-3,4,5,6-tetrahydro-2H-pyran

(1S,3R,5R)-3-{3-[4-(2-Methyl-imidazol-1-yl)-phenylsulfanyl]-phenyl}-8-oxa-bicyclo[3.2.1]octane-3-carbonitrile

ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

4-cyano-4-{5-fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran