ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Base Information

Chemical Name:ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate
CAS No.:179420-53-2
Molecular Formula:C₂₄H₂₆N₂O₃S
Molecular Weight:422.548
Hs Code.:

Synonyms:ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

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Chemical Property of ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

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Technology Process of ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

There total 11 articles about ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 179420-54-3
4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylic acid

: 179420-53-2
ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:

Reference yield:

: 179420-81-6
methyl 4-(3-mercaptophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

silica-gel: silica-gel

: 179420-75-8
4-(2-methylimidazol-1-yl)phenyl iodide

: 179420-53-2
ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane;

Reference yield:

: 179420-77-0
ethyl 4-(3-bromophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylic acid

: 179420-53-2
ethyl 4-{3-[4-(2-methyl-1H-imidazol-1-yl)phenylthio]phenyl}-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.75 h / -78 - -70 °C

1.2: 21.5 g / hexane; tetrahydrofuran / 4.17 h / -78 - 20 °C

2.1: 17.9 g / HCl / 20 h / Heating

3.1: 12.2 g / aq. sodium periodate / methanol / 1 h / 0 °C

4.1: trifluoroacetic anhydride / 0.5 h / Heating

4.2: Et₃N; MeOH

5.1: 0.90 g / Pd(PPh₃)4; t-BuONa / Heating

With hydrogenchloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; trifluoroacetic anhydride; sodium t-butanolate; In tetrahydrofuran; methanol; hexane;
DOI:10.1248/cpb.53.965