1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine

Base Information

• Chemical Name: 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine
• CAS No.: 1035648-59-9
• Molecular Formula: C₃₃H₄₄N₄O₇SSi
• Molecular Weight: 668.886

Synonyms:1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine

Chemical Property of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine

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Technology Process of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine

There total 1 articles about 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)thymine (1035648-40-8) + methyl iodide (74-88-4) → 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine (1035648-59-9)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1016/j.bmc.2008.02.026

Reference yield: 90.0%

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-benzylsulfonyl-3'-N-methyl-β-D-ribofuranosyl)-3-N-methylthymine (1035648-59-9) → [1-[5'-O-benzyl-2'-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-3''-(4''-amino-2'',3''-dihydro-2''-N-methyl-1'',1''-dioxo-isothiazole-5''-phenyl) (1035648-61-3)

Guidance literature:

With caesium carbonate; In acetonitrile; for 0.416667h; Heating;

DOI:10.1016/j.bmc.2008.02.026

upstream raw materials:

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)thymine

methyl iodide

Downstream raw materials:

[1-[5'-O-benzyl-2'-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-methylthymine]-3'-spiro-3''-(4''-amino-2'',3''-dihydro-2''-N-methyl-1'',1''-dioxo-isothiazole-5''-phenyl)

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