3,4-dimethylene-2-phenyloxepane

Base Information

Chemical Name:3,4-dimethylene-2-phenyloxepane
CAS No.:1325730-75-3
Molecular Formula:C₁₄H₁₆O
Molecular Weight:200.28
Hs Code.:

Synonyms:3,4-dimethylene-2-phenyloxepane

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Chemical Property of 3,4-dimethylene-2-phenyloxepane

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Technology Process of 3,4-dimethylene-2-phenyloxepane

There total 6 articles about 3,4-dimethylene-2-phenyloxepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1325730-74-2
4-((trimethylsilyl)methyl)hexa-4,5-dien-1-ol

: 100-52-7
benzaldehyde

: 1325730-75-3
3,4-dimethylene-2-phenyloxepane

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at -78 ℃; for 2.16667h; Inert atmosphere;
DOI:10.1002/asia.201100162

Reference yield:

: 62992-46-5
1-(tetrahydropyranyloxy)-4-pentyn

: 1325730-75-3
3,4-dimethylene-2-phenyloxepane

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / diethyl ether / -78 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: copper(I) bromide; lithium bromide / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether / 0.5 h / -78 - 20 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 0 - 20 °C / Inert atmosphere

5: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 2.17 h / -78 °C / Inert atmosphere

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; toluene-4-sulfonic acid; triethylamine; copper(I) bromide; lithium bromide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 5: Prins type cyclization;
DOI:10.1002/asia.201100162

Reference yield:

: 1146897-00-8
6-(tetrahydro-2H-pyran-2-yloxy)hex-2-ynyl methanesulfonate

: 1325730-75-3
3,4-dimethylene-2-phenyloxepane

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide; lithium bromide / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether / 0.5 h / -78 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 1 h / 0 - 20 °C / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 2.17 h / -78 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; toluene-4-sulfonic acid; copper(I) bromide; lithium bromide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; 3: Prins type cyclization;
DOI:10.1002/asia.201100162