(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

Base Information

Chemical Name:(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate
CAS No.:1233194-95-0
Molecular Formula:C₁₈H₂₂ClNO₇
Molecular Weight:399.828
Hs Code.:

Synonyms:(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

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Chemical Property of (Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

Chemical Property:

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Technology Process of (Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

There total 2 articles about (Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1233194-94-9
C₁₄H₂₄NO₉P

: 125629-45-0
2-chloro-3-acetyloxy-4-methoxybenzaldehyde

: 1233194-95-0
(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

Guidance literature:: C₁₄H₂₄NO₉P; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.0166667h;

2-chloro-3-acetyloxy-4-methoxybenzaldehyde; In dichloromethane; at 0 ℃; for 2h;
DOI:10.3906/kim-0904-14

Reference yield:

: 125629-45-0
2-chloro-3-acetyloxy-4-methoxybenzaldehyde

: 207863-56-7
N-tert-Butoxycarbonyl-α-(diethoxyphosphoryl)glycine methyl ester

: 1233194-95-0
(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

Guidance literature:: N-tert-Butoxycarbonyl-α-(diethoxyphosphoryl)glycine methyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 4 ℃; for 0.0166667h; Inert atmosphere;

2-chloro-3-acetyloxy-4-methoxybenzaldehyde; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield: 89.1%

: 1233194-95-0
(Z)-methyl 3-(3-acetyloxy-2-chloro-4-methoxyphenyl)-2-(tert-butoxycarbonylamino)acrylate

: 1233194-96-1
(S)-N-tert-butoxycarbonyl-(3-acetyloxy-2-chloro-4-methoxy)phenylalanine methyl ester

Guidance literature:: With [(S,R)-DIPAMP-Rh(COD)]BF₄; hydrogen; In acetone; at 25 ℃; for 42h; under 760.051 Torr; optical yield given as %ee; Inert atmosphere;
DOI:10.3906/kim-0904-14