(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Base Information

Chemical Name:(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide
CAS No.:444759-99-3
Molecular Formula:C₂₄H₃₈N₂O₅Si
Molecular Weight:462.662
Hs Code.:

Synonyms:(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Suppliers and Price of (4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

There total 6 articles about (4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 444759-98-2
(4Z,6E)-(2S,3S)-3-Hydroxy-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

: 444759-99-3
(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ol026069o

Reference yield:

: 58550-34-8,37524-18-8
(E)-2-methyl-3-(4-nitrophenyl)acrylaldehyde

: 444759-99-3
(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / KHMDS; 18-crown-6 / tetrahydrofuran / -78 °C

2: 89 percent / DIBAH / CH₂Cl₂ / -78 °C

3: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

4: Bu₂BOTf; triethylamine / tetrahydrofuran / -78 - 0 °C

5: 78 percent / AlMe₃ / toluene / 20 °C

6: 99 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide / 20 °C

With 1H-imidazole; dmap; 18-crown-6 ether; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; potassium hexamethylsilazane; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Still-Gennari reaction / 3: Dess-Martin oxidation;
DOI:10.1021/ol026069o

Reference yield:

: 639008-87-0
2,4-dimethyl-5-(4-nitro-phenyl)-penta-(Z)-2,(E)-4-dienal

: 444759-99-3
(4Z,6E)-(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-7-(4-nitro-phenyl)-hepta-4,6-dienoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Bu₂BOTf; triethylamine / tetrahydrofuran / -78 - 0 °C

2: 78 percent / AlMe₃ / toluene / 20 °C

3: 99 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide / 20 °C

With 1H-imidazole; dmap; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol026069o