N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Base Information

Chemical Name:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide
CAS No.:1445879-80-0
Molecular Formula:C₃₁H₂₇FN₄O₆S₂
Molecular Weight:634.709
Hs Code.:

Synonyms:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Suppliers and Price of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

There total 11 articles about N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445880-81-8
7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

: 5720-06-9
2-Methoxyphenylboronic acid

: 1445879-80-0
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-80-0
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: ethanol / 2 h / Reflux

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

With chlorosulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1445879-89-9
7-bromo-4-chloro-N-cyclopropyl-3-quinolinesulfonamide

: 1445879-80-0
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(2-methoxyphenyl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; ethanol; water;