Technology Process of 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide
There total 7 articles about 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trichlorophosphate / 3 h / Reflux
2: triethylamine / dichloromethane / 1 h / 0 °C
3: ethanol / 2 h / Reflux
With
triethylamine; trichlorophosphate;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride; copper dichloride / -5 - 0 °C
2: ammonia / water; tetrahydrofuran / 0.5 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
4: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 760.05 Torr
5: ethanol / 2 h / Reflux
With
thionyl chloride; 5%-palladium/activated carbon; ammonia; hydrogen; potassium carbonate; copper dichloride;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonia / water; tetrahydrofuran / 0.5 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
3: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 760.05 Torr
4: ethanol / 2 h / Reflux
With
5%-palladium/activated carbon; ammonia; hydrogen; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
