7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Base Information

Chemical Name:7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide
CAS No.:1445880-81-8
Molecular Formula:C₂₄H₂₀BrFN₄O₅S₂
Molecular Weight:607.481
Hs Code.:

Synonyms:7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Suppliers and Price of 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

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Chemical Property of 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Chemical Property:

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Technology Process of 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

There total 7 articles about 7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445880-81-8
7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / 0 °C

3: ethanol / 2 h / Reflux

With triethylamine; trichlorophosphate; In ethanol; dichloromethane;

Reference yield:

: 3,5-dinitrophenyldiazonium tetrafluoroborate

: 1445880-81-8
7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride; copper dichloride / -5 - 0 °C

2: ammonia / water; tetrahydrofuran / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

4: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 760.05 Torr

5: ethanol / 2 h / Reflux

With thionyl chloride; 5%-palladium/activated carbon; ammonia; hydrogen; potassium carbonate; copper dichloride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 31206-25-4
3,5-dinitrobenzene-1-sulfonyl chloride

: 1445880-81-8
7-bromo-N-cyclopropyl-4-(3-(4-fluorophenoxy)-5-sulfamoylphenylamino)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / water; tetrahydrofuran / 0.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

3: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 760.05 Torr

4: ethanol / 2 h / Reflux

With 5%-palladium/activated carbon; ammonia; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;