Technology Process of 5-amino-3-difluoromethyl-3-(2-fluoro-5-nitrophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester
There total 9 articles about 5-amino-3-difluoromethyl-3-(2-fluoro-5-nitrophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester;
With
sulfuric acid; potassium nitrate;
at 30 ℃;
for 0.5h;
With
sodium carbonate; sodium hydroxide;
In
water;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -65 °C
1.2: -80 - -40 °C
2.1: toluene / 4 h / 105 °C / Industry scale
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C
4.1: zinc; acetic acid / 2 h / 20 - 40 °C
5.1: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C
7.1: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice
8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
9.1: potassium nitrate; sulfuric acid / 0.5 h / 30 °C
9.2: Cooling with ice
With
hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium nitrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene / 4 h / 105 °C / Industry scale
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C
3.1: zinc; acetic acid / 2 h / 20 - 40 °C
4.1: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C
6.1: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice
7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
8.1: potassium nitrate; sulfuric acid / 0.5 h / 30 °C
8.2: Cooling with ice
With
hydrogenchloride; sulfuric acid; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium nitrate; N-ethyl-N,N-diisopropylamine; zinc;
5% Pd(II)/C(eggshell);
In
1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;
