5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester
CAS No.:1313526-19-0
Molecular Formula:C₁₄H₁₃Cl₃F₃N₃O₂
Molecular Weight:418.63
Hs Code.:

Synonyms:5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Suppliers and Price of 5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

There total 8 articles about 5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313526-17-8
[2-tert-butoxycarbonylamino-3,3-difluoro-2-(2-fluorophenyl)-propyl]cyanomethylcarbamic acid 2,2,2-trichloroethyl ester

: 1313526-19-0
5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1313526-19-0
5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -65 °C

1.2: -80 - -40 °C

2.1: toluene / 4 h / 105 °C / Industry scale

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

4.1: zinc; acetic acid / 2 h / 20 - 40 °C

5.1: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C

7.1: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1262860-01-4
[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

: 1313526-19-0
5-amino-3-difluoromethyl-3-(2-fluorophenyl)-3,6-dihydro-2H-pyrazine-1-carboxylic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 25 °C

2: zinc; acetic acid / 2 h / 20 - 40 °C

3: hydrogen; sodium acetate / 5% Pd(II)/C(eggshell) / ethanol

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 80 °C

5: sodium hydrogencarbonate / dichloromethane; water / 3.67 h / 25 - 26 °C / Cooling with ice

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; hydrogen; sodium acetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; zinc; 5% Pd(II)/C(eggshell); In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;