Technology Process of C16H16F3NO3S
There total 7 articles about C16H16F3NO3S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H18F3NO2S2;
With
methyl iodide;
In
methanol; water;
at 20 ℃;
for 0.5h;
Cooling with ice;
With
water; sodium hydrogencarbonate;
pH=3 - Ca. 7;
Reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere
1.2: 0.08 h
2.1: methyl iodide; water / methanol / 0.5 h / 20 °C / Cooling with ice
With
copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; water; methyl iodide;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C
2.1: sodium tetrahydroborate; iodine; methanol / tetrahydrofuran / 2 h / 0 - 5 °C / Reflux
3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
5.1: isopropylmagnesium bromide / tetrahydrofuran / -20 °C / Inert atmosphere
5.2: 0.25 h / -5 °C / Inert atmosphere
5.3: 0.08 h
6.1: methyl iodide / water; methanol / 0.5 h / 20 °C / Cooling with ice
6.2: pH 3 - Ca. 7 / Reflux
With
methanol; sodium tetrahydroborate; iodine; isopropylmagnesium bromide; sodium hydride; triethylamine; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; water;
