5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Base Information

• Chemical Name: 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
• CAS No.: 911836-90-3
• Molecular Formula: C₄₁H₅₁N₄O₉P
• Molecular Weight: 774.851

Synonyms:5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Chemical Property of 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

There total 2 articles about 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine (852155-65-8) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite (911836-90-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/cbic.201900590

Reference yield:

2'-O-methyluridine (2140-76-3) → 5'-O-4,4'-dimethoxytrityl-N3,O2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite (911836-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: pyridine; dmap / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/cbic.201900590

upstream raw materials:

5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

2'-O-methyluridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 911836-90-3 5'-O-4,4'-dimethoxytrityl-N³,O^2'-dimethyluridine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Send

Send

Metric Ton KG G Pound L ML

Send

Send