1-(2,5-Difluorobenzyl)piperazine

Base Information

Chemical Name:1-(2,5-Difluorobenzyl)piperazine
CAS No.:179334-18-0
Molecular Formula:C₁₁H₁₄F₂N₂
Molecular Weight:212.242
Hs Code.:2933599090
European Community (EC) Number:623-670-1
DSSTox Substance ID:DTXSID50382601
Nikkaji Number:J3.264.410D
Wikidata:Q82173957
Mol file:179334-18-0.mol

Synonyms:1-(2,5-Difluorobenzyl)piperazine;179334-18-0;1-[(2,5-difluorophenyl)methyl]piperazine;1-(2 5-Difluorobenzyl)piperazine 97;1-(2,5-Difluorobenzyl)piperazin;2,5-difluoro benzyl piperazine;SCHEMBL2922854;DTXSID50382601;GS1940;MFCD05189212;1-(2,5-Difluoro-benzyl)-piperazine;AKOS009157483;1-(2,5-Difluorobenzyl)piperazine, 97%;1-(25-DIFLUOROBENZYL)PIPERAZINE97;BB 0249451;EN300-1848122

Suppliers and Price of 1-(2,5-Difluorobenzyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(2,5-DIFLUOROBENZYL)PIPERAZINE 95.00%
5G
$ 1093.29

American Custom Chemicals Corporation
1-(2,5-DIFLUOROBENZYL)PIPERAZINE 95.00%
1G
$ 688.12

Alfa Aesar
1-(2,5-Difluorobenzyl)piperazine, 97%
5g
$ 253.00

Alfa Aesar
1-(2,5-Difluorobenzyl)piperazine, 97%
1g
$ 65.70

Alfa Aesar
1-(2,5-Difluorobenzyl)piperazine, 97%
250mg
$ 22.70

Total 14 raw suppliers

Chemical Property of 1-(2,5-Difluorobenzyl)piperazine

Chemical Property:

Vapor Pressure:0.00652mmHg at 25°C
Refractive Index:n20/D 1.517
Boiling Point:271.3°Cat760mmHg
Flash Point:117.9°C
PSA：15.27000
Density:1.177g/cm³
LogP:1.63670
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:212.11250478
Heavy Atom Count:15
Complexity:195

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2,5-DIFLUOROBENZYL)PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CN(CCN1)CC2=C(C=CC(=C2)F)F

Technology Process of 1-(2,5-Difluorobenzyl)piperazine

There total 3 articles about 1-(2,5-Difluorobenzyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 179334-18-0
4-(2,5-difluorobenzyl)piperazine

Guidance literature:

Reference yield:

: C₁₆H₂₂F₂N₂O₂

: 179334-18-0
4-(2,5-difluorobenzyl)piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.0c02081

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 179334-18-0
4-(2,5-difluorobenzyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.0c02081