(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

Base Information

Chemical Name:(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone
CAS No.:852907-95-0
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

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Chemical Property of (+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

Chemical Property:

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Technology Process of (+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

There total 4 articles about (+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (+/-)-trans-4-(1-ethoxycarbonyl-1-methylethyl)-3-hydroxy-1-(4-methoxyphenyl)-2-azetidinone

: 852907-95-0
(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

Guidance literature:: With phosphorus pentoxide; dimethyl sulfoxide; at 20 ℃; for 49h;
DOI:10.1139/v04-159

Reference yield:

: 3-[(E)-4-Methoxy-phenylimino]-2,2-dimethyl-propionic acid ethyl ester

: 852907-95-0
(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: POCl₃; Et₃N / 48 h / 20 °C

1.2: 2.8 g / KOH / tetrahydrofuran / 2 h / 0 °C

2.1: 71 percent / P₂O₅; DMSO / 49 h / 20 °C

With phosphorus pentoxide; dimethyl sulfoxide; triethylamine; trichlorophosphate; 1.1: Staudinger reaction;
DOI:10.1139/v04-159

Reference yield:

: 116594-66-2
3,3-diethoxy-2,2-dimethylpropionic acid ethyl ester

: 852907-95-0
(+/-)-(1-ethoxycarbonyl-1-methylethyl)-1-(4-methoxyphenyl)-3-oxo-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-toluenesulfonic acid monohydrate / 5 h / Heating

2.1: POCl₃; Et₃N / 48 h / 20 °C

2.2: 2.8 g / KOH / tetrahydrofuran / 2 h / 0 °C

3.1: 71 percent / P₂O₅; DMSO / 49 h / 20 °C

With phosphorus pentoxide; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trichlorophosphate; 2.1: Staudinger reaction;
DOI:10.1139/v04-159