2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Name:2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1361224-52-3
Molecular Formula:C₂₁H₁₈ClF₆N₃O₃S
Molecular Weight:541.902
Hs Code.:

Synonyms:2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 6 articles about 2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1361224-72-7
1,1,1,3,3,3-hexafluoro-2-(4-(2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-2-propanol

: 1361224-52-3
2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

Reference yield:

: 1361224-49-8
benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate

: 1361224-52-3
2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / -10 - 20 °C

1.2: 2 h

2.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 1.5 h / 100 °C / sealed vessel; Inert atmosphere

3.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 0.25 h / 20 °C

3.2: pH ~ 7

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

With trifluorormethanesulfonic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In dichloromethane; toluene;

Reference yield:

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1361224-52-3
2-(4-(4-((6-chloro-3-pyridinyl)sulphonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / ruphos; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct / toluene / 1.5 h / 100 °C / sealed vessel; Inert atmosphere

2.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 0.25 h / 20 °C

2.2: pH ~ 7

3.1: triethylamine / dichloromethane / 0.17 h / 0 °C

With trifluorormethanesulfonic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct; ruphos; In dichloromethane; toluene;