(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

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Chemical Name:(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate
CAS No.:127517-85-5
Molecular Formula:C₂₁H₃₅O₇P
Molecular Weight:430.478
Hs Code.:

Synonyms:(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

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Chemical Property of (S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

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Technology Process of (S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

There total 6 articles about (S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 127517-84-4
((S)-3-Benzyloxy-1-hydroxymethyl-propoxymethyl)-phosphonic acid diethyl ester

: 127517-85-5
(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

Guidance literature:: With toluene-4-sulfonic acid; In diethyl ether; dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/jm00168a039

Reference yield:

: 71998-69-1,86990-91-2,104973-80-0,69985-32-6
(S)-4-benzyloxy-1,2-butanediol

: 127517-85-5
(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1.) 0 deg C, 90 min, 2.) 16 h

2: 1.) NaH / 1.) mineral oil, THF, 60 deg C, 3 h, 2.) 25 deg C, 16 h

3: 93 percent / Amberlyst 15 / methanol / 4 h / 25 °C

4: 95 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂; diethyl ether / 2 h / 25 °C

With Amberlyst 15; sodium hydride; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00168a039

Reference yield:

: 82780-39-0
(S)-4-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolane

: 127517-85-5
(S)-diethyl <<3-(benzyloxy)-1-<(tetrahydro-2H-pyran-2-yloxy)methyl>propoxy>methyl>phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 3 N HCl / methanol / 4 h / 25 °C

2: Et₃N / CH₂Cl₂ / 1.) 0 deg C, 90 min, 2.) 16 h

3: 1.) NaH / 1.) mineral oil, THF, 60 deg C, 3 h, 2.) 25 deg C, 16 h

4: 93 percent / Amberlyst 15 / methanol / 4 h / 25 °C

5: 95 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂; diethyl ether / 2 h / 25 °C

With hydrogenchloride; Amberlyst 15; sodium hydride; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00168a039