82780-39-0Relevant articles and documents
Carbohydrate-Catalyzed Enantioselective Alkene Diboration: Enhanced Reactivity of 1,2-Bonded Diboron Complexes
Fang, Lichao,Yan, Lu,Haeffner, Fredrik,Morken, James P.
, p. 2508 - 2511 (2016/03/12)
Catalytic enantioselective diboration of alkenes is accomplished with readily available carbohydrate-derived catalysts. Mechanistic experiments suggest the intermediacy of 1,2-bonded diboronates.
MATRIX METALLOPROTEINASE INHIBITORS
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Page/Page column 81-82, (2012/04/10)
The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.
Process for producing butanetriol derivative
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, (2008/06/13)
A process for preparing a butanetriol derivative of the formula (1) useful as intermediates of medicines wherein R1is the same defined below, which comprises reacting a compound of the formula (3) wherein R1and R2are the different protecting groups, and an ethylene glycol derivative in a basic condition to prepare a compound of the formula (4) or (4a) wherein R1and R2are the same defined above, and then subjecting the compound (4) or (4a) to selective deprotection reaction.
Synthesis of (S)- and (R)-3-hydroxyhexadecanoic acid
Jakob, Barbara,Voss, Gundula,Gerlach, Hans
, p. 3255 - 3262 (2007/10/03)
Diol (R)-(+)-3 is prepared either from the hydroxyketone 2 by reduction with fermenting baker's yeast or by hydrolysis of the dioxolane (R)-(+)-1 which is available from dimethyl D-malate as starting material. (R)-(+)-3 could be converted stereoselectively into (R)-(+)-4. Reaction of (+)-4 with dodecylmagnesium bromide yielded the alcohol (S)-(-)-5 with >99% ee. Its acetylation gave (S)-(+)-6 and hydrogenolysis gave the primary alcohol (S)-(+)-7 which could be oxidized selectively to (S)-(+)-8 wih NaIO4/RuCl3. Alkaline hydrolysis of (+)-8 yielded 3-hydroxyhexadecanoic acid (S)-(+)-9 which could be esterified to give the methyl ester (S)-(+)-10 with >99% ee. Starting with the dioxolane (S)-(-)-1, derived from dimethyl L-malate, the 3-hydroxyhexadecanoic acid (R)-(-)-10 could be synthesised via the intemediates (S)-(-)-3, (S)-(-)-4, (R)-(+)-5, (R)-(-)-6, (R)-(-)-7 and (R)-(-)-8. Copyright (C) Elsevier Science Ltd.
A Difference CD Method for Determining Absolute Stereochemistry of Acyclic 1,2,4-Triols
Mori, Yuji,Furukawa, Hiroshi
, p. 6725 - 6738 (2007/10/02)
A general method based on difference circular dichroic (DIF CD) spectroscopy for assigning the absolute configuration of 1,2,4-triol is presented.Four possible stereoisomers of 6-heptene-1,2,4-triol were prepared and served as models to develop the procedure.The sign of the DIF CD Cotton effect is correlated to the absolute configuration of the C2 position.
A NEW SYNTHETIC APPROACH TO (R)-GABOB FROM L-MALIC ACID
Misiti, Domenico,Zappia, Giovanni,Monache, Giuliano Delle
, p. 219 - 222 (2007/10/02)
A synthesis of (R)-4-amino-3-hydroxybutanoic acid, starting from L-malic acid, is reported.The synthetic approach involves an inversion of configuration of the chiral centre to obtain the correct stereochemistry, together with the protection of the 1,2-am
Enzyme-mediated enantioselective hydrolysis of cyclic carbonates
Matsumoto, Kazutsugu,Fuwa, Seiji,Kitajima, Hidehiko
, p. 6499 - 6502 (2007/10/02)
The enzyme-mediated enantioselective hydrolysis of cyclic carbonates is disclosed. Racemic 4-(2-benzyloxy)ethyl-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-benzyloxybutane-1,2-diol (2a). PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enantioselectivity.
Regioselective protection of triols to cyclic carbonates
Kang,Jeon,Nam,Park,Lee
, p. 305 - 312 (2007/10/02)
Regioselective protection of 1,2,3-, 1,2,4-, and 1,2,5-triols to 5- membered cyclic carbonates with triphosgene, dimethyl carbonate, or carbonyldiimidazole is described.
Synthesis and Antiviral Activity of (S)-9-guanine
Kim, Choung Un,Luh, Bing Yu,Martin, John C.
, p. 1797 - 1800 (2007/10/02)
The synthesis of (S)-9-guanine (3), starting from (S)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (4), is described.Alkylation of trityl derivative 7 with (diethylphosphono)methyl triflate provided phosphonate 8, whi
