ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

Base Information

Chemical Name:ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate
CAS No.:173974-89-5
Molecular Formula:C₁₇H₁₈F₂N₂O₃S
Molecular Weight:368.404
Hs Code.:

Synonyms:ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

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Chemical Property of ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

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Technology Process of ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

There total 1 articles about ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.5%

: 118460-39-2
ethyl 2,2-difluoro-3-hydroxy-5-phenylpentanoate

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 173974-89-5
ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

Guidance literature:: In 1,2-dichloro-ethane; at 72 ℃; for 3h;
DOI:10.1016/0040-4020(95)00858-6

Reference yield: 81.9%

: 173974-89-5
ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

: 128483-82-9
ethyl 2,2-difluoro-5-phenylpentanoate

Guidance literature:: With tri-n-butyl-tin hydride; In toluene; for 3h; Heating;
DOI:10.1016/0040-4020(95)00858-6

Reference yield:

: 173974-89-5
ethyl 2,2-difluoro-3-(imidazol-1-yl)thiocarbonyloxy-5-phenylpentanoate

: (2S,3R)-4,4-difluoro-2-methyl-5-phenylheptane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 81.9 percent / n-Bu₃SnH / toluene / 3 h / Heating

2: 83.3 percent / Dibal-H / 0.5 h / -78 °C

3: toluene / Heating

4: 1.) n-Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, -78 deg C, 10 min; 0 deg C, 1 h, 2.) CH₂Cl₂, -5 deg C, 0.5 h

5: 89.2 percent / LiBH₄ / tetrahydrofuran / 1 h / Ambient temperature

With lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; tri-n-butyl-tin hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/0040-4020(95)00858-6