(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Base Information

Chemical Name:(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one
CAS No.:591253-54-2
Molecular Formula:C₁₉H₁₇Br₂FN₄O₄S
Molecular Weight:576.241
Hs Code.:

Synonyms:(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

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Chemical Property of (5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

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Technology Process of (5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

There total 5 articles about (5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 591253-50-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-carboxaldehyde-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

: 591253-54-2
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield: 89.0%

: 558-13-4
carbon tetrabromide

: 591253-50-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-carboxaldehyde-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

: 591253-54-2
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: With triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jm0400810

Reference yield:

: 371195-52-7
(5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-azidomethyloxazolidin-2-one

: 591253-54-2
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(2,2-dibromoethenyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2: 50 percent / N-methylpyrrolidone / 4 h / 90 °C

3: 84 percent / oxalyl chloride; DMSO; N,N-diisopropylethylamine / CH₂Cl₂; 1-methyl-pyrrolidin-2-one / 1 h / -50 - -20 °C

4: 89 percent / PPh₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With 1-methyl-pyrrolidin-2-one; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; dichloromethane; 3: Swern oxidation;
DOI:10.1021/jm0400810