(S)-3-{(R)-2-[(S)-(4-(benzyloxyphenyl))-(4-fluorophenylamino)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one

Base Information

• Chemical Name: (S)-3-{(R)-2-[(S)-(4-(benzyloxyphenyl))-(4-fluorophenylamino)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one
• CAS No.: 954109-20-7
• Molecular Formula: C₄₂H₃₈F₂N₂O₆
• Molecular Weight: 704.77
• Mol file: 954109-20-7.mol

Synonyms:(S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

Chemical Property of (S)-3-{(R)-2-[(S)-(4-(benzyloxyphenyl))-(4-fluorophenylamino)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-{(R)-2-[(S)-(4-(benzyloxyphenyl))-(4-fluorophenylamino)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one

There total 2 articles about (S)-3-{(R)-2-[(S)-(4-(benzyloxyphenyl))-(4-fluorophenylamino)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one (942485-56-5) + benzyl bromide (100-39-0) + (Z)-4-hydroxybenzylidene-4-fluorophenylamine (3382-63-6,942485-62-3) → (S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one (954109-20-7)

Guidance literature:

benzyl bromide; (Z)-4-hydroxybenzylidene-4-fluorophenylamine; With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; for 3h; Reflux;

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one; With titanium(IV) tetraethanolate; titanium tetrachloride; In dichloromethane; at -15 ℃; for 3h; Time; Inert atmosphere;

Reference yield: 58.0%

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one (942485-56-5) + 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine (70627-52-0,1206694-75-8) → (S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one (954109-20-7)

Guidance literature:

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one; With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.666667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine; Product distribution / selectivity;

Reference yield: 95.3%

(S)-3-{(R)-2-[(S)-[4-(benzyloxy)phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)[1,3]dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one (954109-20-7) → C40H34F2N2O5 (1185883-43-5)

Guidance literature:

With water; toluene-4-sulfonic acid; In acetone; for 4h; Reflux;

upstream raw materials:

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine

benzyl bromide

(Z)-4-hydroxybenzylidene-4-fluorophenylamine

Downstream raw materials:

(3R,4S)-4-(4-benzyloxyphenyl)-1-(4-fluoro phenyl)-3-{2-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]ethyl}azetidin-2-one

C₄₀H₃₄F₂N₂O₅

C₄₀H₃₆F₂N₂O₅