(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Base Information

Chemical Name:(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol
CAS No.:1092443-51-0
Molecular Formula:C₂₃H₃₃FN₆O
Molecular Weight:428.553
Hs Code.:

Synonyms:(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Suppliers and Price of (R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

There total 9 articles about (R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1092444-39-7
[(R)-6-{7-[tert-butoxycarbonyl-(2-fluoro-benzyl)-amino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-5-ylamino}-7-hydroxy-heptyl]-carbamic acid tert-butyl ester

: 1092443-51-0
(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Guidance literature:: [(R)-6-{7-[tert-butoxycarbonyl-(2-fluoro-benzyl)-amino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-5-ylamino}-7-hydroxy-heptyl]-carbamic acid tert-butyl ester; With hydrogenchloride; methanol; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 771510-25-9
3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol

: 1092443-51-0
(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 16 h / Heating / reflux

2.1: ethanol / 3 h / Heating / reflux

3.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

4.2: 12 h / 100 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

6.1: hydrogenchloride; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; tetrabutyl ammonium fluoride; sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 625-28-5
Isovaleronitrile

: 1092443-51-0
(R)-2-(7-(2-fluorobenzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-ylamino)-7-aminoheptanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 16.5 h / -78 - 20 °C

1.3: pH 3

2.1: acetic acid; hydrazine / ethanol / 16 h / Heating / reflux

3.1: sodium / ethanol / 16 h / Heating / reflux

3.2: pH 3

4.1: trichlorophosphate / 16 h / Heating / reflux

5.1: ethanol / 3 h / Heating / reflux

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

7.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

7.2: 12 h / 100 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

9.1: hydrogenchloride; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; tetrabutyl ammonium fluoride; sodium; acetic acid; sodium t-butanolate; hydrazine; lithium diisopropyl amide; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;