2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine

Base Information

• Chemical Name: 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine
• CAS No.: 97150-66-8
• Molecular Formula: C₁₄H₁₂N₆O₂
• Molecular Weight: 296.288
• Mol file: 97150-66-8.mol

Synonyms:2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine

Chemical Property of 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine

There total 2 articles about 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydroxy<2-<4-(1H-imidazol-1-yl)phenyl>-2-oxoethyl>propanedioic acid diethyl ester (97150-79-3) → 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine (97150-66-8)

Guidance literature:

With hydrazine hydrate; In methanol; for 18h; Heating;

DOI:10.1021/jm00148a006

Reference yield:

4'-(imidazol-1-yl)acetophenone (10041-06-2) → 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine (97150-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 g / 3 h / 95 - 100 °C

2: 80.2 g / hydrazine hydrate / methanol / 18 h / Heating

With hydrazine hydrate; In methanol;

DOI:10.1021/jm00148a006

Reference yield: 22.0%

2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine (97150-66-8) → 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone (97150-65-7)

Guidance literature:

With hydrogenchloride; sodium nitrite; 1.) 5 deg C, 2.) heating;;

DOI:10.1002/jhet.5570230551

upstream raw materials:

hydroxy<2-<4-(1H-imidazol-1-yl)phenyl>-2-oxoethyl>propanedioic acid diethyl ester

4'-(imidazol-1-yl)acetophenone

Downstream raw materials:

4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone

2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrochloride

2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxamide